Articular cartilage development: a molecular perspective.

Facundo Las Heras, Harpal K Gahunia, Kenneth P H Pritzker

University of Chile Clinical Hospital, University of Chile, 999 Santos Dumont Avenue, Santiago, Chile. facundo.lasheras@utoronto.ca

The Orthopedic clinics of North America 2012 Apr

filter terms:

In this article, development of articular cartilage and endochondral ossification is reviewed, from the perspective of both morphologic aspects of histogenesis and molecular biology, particularly with respect to key signaling molecules and extracellular matrix components most active in cartilage development. The current understanding of the roles of transforming growth factor β and associated signaling molecules, bone morphogenic proteins, and molecules of the Wnt-β catenin system in chondrogenesis are described. Articular cartilage development is a highly conserved complex biological process that is dynamic and robust in nature, which proceeds well without incident or failure in all joints of most young growing individuals. Copyright © 2012 Elsevier Inc. All rights reserved.

Citation

Facundo Las Heras, Harpal K Gahunia, Kenneth P H Pritzker. Articular cartilage development: a molecular perspective. The Orthopedic clinics of North America. 2012 Apr;43(2):155-71, v