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Rotaxanes and biofunctionalized pseudorotaxanes via thiol-maleimide click chemistry.
Umesh Choudhary, Brian H Northrop
Department of Chemistry, Wesleyan University, Middletown, Connecticut 06459, USA.
Organic letters 2012 Apr 20Sizes of these terms reflect their relevance to your search.
Base-catalyzed thiol-maleimide click chemistry has been applied to the synthesis of neutral donor-acceptor [2]rotaxanes in good yield. This method is extended further to the synthesis of a glutathione-functionalized [2]pseudorotaxane, a precursor to integrated conjugates of interlocked molecules with proteins and enzymes. © 2012 American Chemical Society
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Umesh Choudhary, Brian H Northrop. Rotaxanes and biofunctionalized pseudorotaxanes via thiol-maleimide click chemistry. Organic letters. 2012 Apr 20;14(8):2082-5
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PMID: 22482430
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