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A series of novel 1,3,4-thiadiazole-containing benzisoselenazolone derivatives were prepared by the condensation of 2-chloroselenobenzoyl chloride and 2-amino-5-substituted-1,3,4-thiadiazole. Their in vitro antiproliferative activities were evaluated in SSMC-7721, MCF-7 and A-549 cells. The results suggest that, in different tumor cells, some compounds have good antiproliferative activity, certain selectivity and potential value of further research. Copyright © 2012 Elsevier Ltd. All rights reserved.


Zhenhua Luo, Baoquan Chen, Shuangyan He, Yanping Shi, Yuming Liu, Caiwen Li. Synthesis and antitumor-evaluation of 1,3,4-thiadiazole-containing benzisoselenazolone derivatives. Bioorganic & medicinal chemistry letters. 2012 May 1;22(9):3191-3

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PMID: 22483583

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