Correlation Engine 2.0
Clear Search sequence regions

We studied 31 children with hemolytic anemia, or with positive family history for hereditary spherocytosis (HS), to assess the reliability of capillary blood samples for the diagnosis. HS was diagnosed in 20 patients. Cryohemolysis (CH) was positive in 94% and eosin-5'-maleimide flow cytometry in 90% of them, whereas flow cytometric osmotic fragility was positive in 94%. Capillary blood sampling showed to be useful for the diagnosis. Simultaneous use of these three tests allows confirming diagnosis in 100% of patients. The use of very small blood volumes (300 µl) allows an earlier diagnosis in neonates and small infants. Copyright © 2012 Wiley Periodicals, Inc.


Renée L Crisp, Liliana Solari, Daniel Gammella, Gabriel A Schvartzman, María Cristina Rapetti, Hugo Donato. Use of capillary blood to diagnose hereditary spherocytosis. Pediatric blood & cancer. 2012 Dec 15;59(7):1299-301

Expand section icon Mesh Tags

Expand section icon Substances

PMID: 22488885

View Full Text