Correlation Engine 2.0
Clear Search sequence regions

Sizes of these terms reflect their relevance to your search.

It has become apparent in the last years that metal ion homeostasis and its dysfunction which results in increased accumulation in brain, notably of copper, iron and zinc, may be associated with a number of neurodegenerative diseases, such that chelation therapy may be one therapeutic option. We briefly outline chelators currently available together with strategies to develop new chelators capable of crossing the blood-brain-barrier. The homeostasis of iron in brain together with changes in brain iron with ageing are reviewed as well as the role of iron in Parkinson's disease, and the potential of chelation therapy in PD. Copper and zinc homeostasis in brain and age associated changes are then outlined, along with a discussion of the possible involvement of Zn, Cu and Fe in Alzheimer's disease. We conclude with a brief summary of chelation therapy in AD.


R J Ward, D T Dexter, R R Crichton. Chelating agents for neurodegenerative diseases. Current medicinal chemistry. 2012;19(17):2760-72

Expand section icon Mesh Tags

Expand section icon Substances

PMID: 22489724

View Full Text