Outcomes of chronic radiation intestinal injury treated with surgical interventions].

To explore the surgical approaches and clinical outcomes of chronic radiation intestinal injury (CRII). From January 1, 2001 to December 31, 2010, at Department of Surgery, Nanjing General Hospital of Nanjing Command a consecutive series of 206 CRII patients undergoing surgical interventions was reviewed retrospectively. There were 64 males and 142 females with an age range of (50 ± 11) years old. The indications, surgical approaches, surgical complications and mortality were analyzed. 206 CRII patients received 229 surgical treatment, 31 patients underwent two or more operations. The course of surgical interventions included intestinal obstruction (n = 142), intestinal fistula (n = 56), proctitis (n = 12), bleeding (n = 6) and others (n = 13). They underwent 229 laparotomies including intestinal resection and primary anastomosis (n = 142), intestinal resection and enterostomy (n = 57), exclusion of radiation-related gastrointestinal diseases (n = 14) and other procedures (n = 16). The occurrence rate of postoperative intestinal complications was 25.7% (53/206). Five patients (2.4%) died within the postoperative 28 days. Surgery is often required for patients with chronic radiation-induced intestinal obstruction, fistula, hemorrhage and perforation, etc. Resection and primary anastomosis with undamaged segments may be performed safely in selected patients. And a judicious use of stoma can reduce the rates of major surgical mortality and morbidity.

Citation

You-sheng Li, Ning Li, Yuan-xin Li, Jian-an Ren, Wei-ming Zhu, Yun-zhao Zhao, Jian Wang, Lei Zheng, Jie-shou Li. Outcomes of chronic radiation intestinal injury treated with surgical interventions]. Zhonghua yi xue za zhi. 2012 Jan 10;92(2):91-3

Mesh Tags

PMID: 22490688

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