Zhongliang Wang, Yao Chen, Xiaofeng Li, Li Xu, Wei Ma, Lingmei Chang, Funian Ju
Department of Otolaryngology-Head and Neck Surgery, Subei People's Hospital of Jiangsu Province, Yangzhou, China. zhongliangwangcn@126.com
Asian Pacific journal of cancer prevention : APJCP 2012Expression of vascular endothelial growth factor C (VEGF-C)and vascular endothelial growth factor receptor-3 (VEGFR-3) in laryngeal squamous carcinoma and its relationship to lymph node metastasis were investigated. VEGF-C and VEGFR-3 gene expression in 30 cases of normal laryngeal mucosa tissue (NLM), primary laryngeal carcinoma cell carcinomas (PLC) and cervical lymph nodes (CLN) was examined by reverse transcription polymerase chain reaction (RT-PCR). Protein levels of VEGF-C expression were determined by immunohistochemical staining in 60 cases of PLC. Expression of VEGF-C and VEGFR-3 different among NLM, PLC and CLN in the same patient. In PLC, expression was significantly higher in lymph node positive group than in the lymph node negative group and associated with histological grade of differentiation; Expression of VEGF-C and VEGFR-3 was not linked with age, sex, site or T stage. A close correlation was found between VEGF-C/VEGFR-3 expression and lymph node metastasis in PLC, suggesting a role in metastasis of laryngeal carcinomas.
Zhongliang Wang, Yao Chen, Xiaofeng Li, Li Xu, Wei Ma, Lingmei Chang, Funian Ju. Expression of VEGF-C/VEGFR-3 in human laryngeal squamous cell carcinomas and its significance for lymphatic metastasis. Asian Pacific journal of cancer prevention : APJCP. 2012;13(1):27-31
PMID: 22502683
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