Treatment of late syphilis with 2.4 million units benzathine penicillin G (BPG): tolerance of single versus divided doses.

Michel Janier, Eliane Libar, Annie Bonnet, Patrick Meunier, Magda Tabet, Monique Mathourais, Christine Paterour, Raphael Porcher

Centre des MST, Hôpital St-Louis, AP-HP, Paris, France. michel.janier@sls.aphp.fr

Sexually transmitted diseases 2012 May

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Although there is no data in the literature, some textbooks recommend fractioning the injection of benzathine penicillin G (BPG) for alleviating the pain. In a monocentric study done in 50 consecutive patients with late syphilis. Patients were assigned to receive 1 dose of 2.4 million units BPG intramuscularly the first week and 2 doses of 1.2 million units BPG in each buttock the second week. In the third week, patients were asked to choose between the 2 options. It was demonstrated that the 2 techniques were equally well tolerated and equally preferred by patients.

Citation

Michel Janier, Eliane Libar, Annie Bonnet, Patrick Meunier, Magda Tabet, Monique Mathourais, Christine Paterour, Raphael Porcher. Treatment of late syphilis with 2.4 million units benzathine penicillin G (BPG): tolerance of single versus divided doses. Sexually transmitted diseases. 2012 May;39(5):359-60