Nucleophilic addition of β-amino carbanions to arynes: one-pot synthesis of 4-aryl-N-methyl-1,2,3,4-tetrahydroisoquinolines.

Kamal Nain Singh, Paramjit Singh, Pushpinder Singh, Yadwinder Singh Deol

Department of Chemistry, Panjab University, Chandigarh-160014, India. kns@pu.ac.in

Organic letters 2012 May 4

filter terms:

A novel approach for the direct C-4 arylation of N-methyl-1,2,3,4-tetrahydroisoquinolines by nucleophilic addition of β-aminocarbanions to benzynes is described which provides a one-pot procedure for synthesis of the title compounds.

Citation

Kamal Nain Singh, Paramjit Singh, Pushpinder Singh, Yadwinder Singh Deol. Nucleophilic addition of β-amino carbanions to arynes: one-pot synthesis of 4-aryl-N-methyl-1,2,3,4-tetrahydroisoquinolines. Organic letters. 2012 May 4;14(9):2202-5