Zinc gluconate is an agonist of peroxisome proliferator-activated receptor-α in the epidermis.

Peroxisome proliferator-activated receptors-α (PPARs-α) are nuclear receptors with anti-inflammatory properties. Zinc gluconate is efficient in the treatment of several inflammatory dermatoses. The aim of our work was to determine whether the modulation of PPAR-α expression and activity could be one of the mechanisms of action of zinc gluconate anti-inflammatory activity in inflammatory dermatoses. Thus, we used ex vivo skin explants incubated with lipopolysaccharide (LPS), a pro-inflammatory molecule, with or without zinc gluconate. We evaluated PPAR-α protein expression using immunohistochemistry, PPAR-α DNA-binding activity using an ELISA-like technique, and PPAR-α mRNA levels using quantitative PCR. On the one hand, we found that PPAR-α epidermal protein expression was stimulated by LPS and that LPS suppressed PPAR-α mRNA expression, without modifying its function. On the other hand, in inflammatory LPS-stimulated explants, zinc gluconate significantly upregulated PPAR-α function and mRNA expression level, without changing its epidermal protein expression. These results suggest that zinc gluconate may be a PPAR-α agonist, which might play a role in the anti-inflammatory activity of this molecule. © 2012 John Wiley & Sons A/S.

Citation

Carole Poiraud, Gaëlle Quereux, Anne-Chantal Knol, Rémy Allix, Amir Khammari, Brigitte Dreno. Zinc gluconate is an agonist of peroxisome proliferator-activated receptor-α in the epidermis. Experimental dermatology. 2012 May;21(5):347-51

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PMID: 22509831

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