On chemical structures with potent antiepileptic/anticonvulsant profile.
M N Aboul-Enein, A A El-Azzouny, O A Saleh, Y A Maklad
Medicinal and Pharmaceutical Chemistry Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki, Cairo, Egypt. mnaboulenein@yahoo.com
Mini reviews in medicinal chemistry 2012 JunEpilepsy is a common chronic neurological disorder characterized by recurrent unprovoked seizures. There has been a considerable interest in the development of many antiepileptic and anticonvulsant agents for controlling epilepsy with fewer side effects and improvement of quality of life. Since the terms antiepileptics /anticonvulsants are used interchangeably, this article reviews their classification according to the chemical structure into: hydantoins, oxazolidinediones, succinimides, barbiturates, amides, benzodiazepines, valproic acid and its derivatives, GABA-analogues, cycloalkanes, semicarbazones, γ butyrolactones (GBLs), imidaquinazolines and pyrrolidine derivatives as well as miscellaneous compounds. In addition, the review discusses the different mechanisms of action of antiepileptic and anticonvulsant agents.
Citation
M N Aboul-Enein, A A El-Azzouny, O A Saleh, Y A Maklad. On chemical structures with potent antiepileptic/anticonvulsant profile. Mini reviews in medicinal chemistry. 2012 Jun;12(7):671-700
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PMID: 22512548
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