Cytokine receptor activation at the cell surface.

Sophie E Broughton, Timothy R Hercus, Angel F Lopez, Michael W Parker

St. Vincent's Institute of Medical Research, 9 Princes Street, Fitzroy, Victoria 3065, Australia.

Current opinion in structural biology 2012 Jun

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Cytokines are well recognized for the pleiotropic nature of their signaling and biological activities on many cell types and their role in health and disease. Recent years have seen a steady stream of new cytokine receptor crystal structures including those that are activated by GM-CSF, type I interferon, and a variety of interleukins. Highlights include the observation of a dodecameric signaling complex for the GM-CSF receptor, electron microscopy imaging of an intact gp130/IL-6/IL-6Rα ternary receptor complex bound to its signal transducing Janus kinase and visualization of novel cytokine recognition mechanisms in the interleukin-17 and type I interferon families. This increasing knowledge in cytokine structural biology is driving new opportunities for developing novel therapies to modulate cytokine function in a diverse range of diseases including malignancies and chronic inflammation. Copyright © 2012 Elsevier Ltd. All rights reserved.

Citation

Sophie E Broughton, Timothy R Hercus, Angel F Lopez, Michael W Parker. Cytokine receptor activation at the cell surface. Current opinion in structural biology. 2012 Jun;22(3):350-9