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Epidemic meningococcal meningitis continues to be an important worldwide cause of morbidity and mortality, especially in developing countries. Throughout its relatively brief history, especially over the past century, a number of 'critical episodes' have occurred that have enhanced our understanding of the disease and allowed for its potential control. This article reviews three such 'episodes': the first effective treatment for the disease; the development of the first effective meningococcal vaccine; and the description of its epidemiology in sub-Saharan Africa, where the majority of epidemic meningococcal disease continues to occur. These historical 'episodes' have informed current strategies that may lead to eventual control of epidemic meningococcal meningitis. Copyright © 2012 Elsevier Ltd. All rights reserved.


Andrew W Artenstein, F Marc LaForce. Critical episodes in the understanding and control of epidemic meningococcal meningitis. Vaccine. 2012 Jun 29;30(31):4701-7

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PMID: 22525794

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