Resuscitation-promoting factors (Rpf): in search of inhibitors.

Arseny S Kaprelyants, Galina V Mukamolova, Alessia Ruggiero, Vadim A Makarov, Galina R Demina, Margarita O Shleeva, Vasilii D Potapov, Pavel A Shramko

A. N. Bach Institute of Biochemistry, RAS, Leninsky pr., 33, 119071, Moscow, Russia. arseny@inbi.ras.ru

Protein and peptide letters 2012 Oct

filter terms:

Resuscitation promoting factors (Rpf) are a family of proteins secreted by actively growing actinobacteria, including Mycobacterium tuberculosis. Experimental evidence suggests that Rpfs play a distinct role in bacterial resuscitation and re-growth as well as reactivation of chronic tuberculosis in mice. The striking similarity of the Rpfs structure to cell wall hydrolysing enzymes has provided a basis for the development of novel low molecular weight inhibitors of Rpfs activity. In particular, recently characterised nitrophenylthiocyanate compounds could be considered as a promising scaffold for generation of therapeutic agents targeting reactivation of latent tuberculosis. This review describes recent progress in understanding of molecular mechanisms of Rpf biological activity.

Citation

Arseny S Kaprelyants, Galina V Mukamolova, Alessia Ruggiero, Vadim A Makarov, Galina R Demina, Margarita O Shleeva, Vasilii D Potapov, Pavel A Shramko. Resuscitation-promoting factors (Rpf): in search of inhibitors. Protein and peptide letters. 2012 Oct;19(10):1026-34