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Synthesis of 3,5-disubstituted isoxazoles via Cope-type hydroamination of 1,3-dialkynes.
Liangguang Wang, Xiaoqiang Yu, Xiujuan Feng, Ming Bao
State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116023, China.
Organic letters 2012 May 4Sizes of these terms reflect their relevance to your search.
An efficient method for the synthesis of 3,5-disubstituted isoxazoles is described. The reactions of 1,3-dialkynes with hydroxylamine proceeded smoothly in DMSO under mild reaction conditions to produce 3,5-disubstituted isoxazoles in satisfactory to excellent yields.
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Liangguang Wang, Xiaoqiang Yu, Xiujuan Feng, Ming Bao. Synthesis of 3,5-disubstituted isoxazoles via Cope-type hydroamination of 1,3-dialkynes. Organic letters. 2012 May 4;14(9):2418-21
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PMID: 22537143
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