MSI and LOH in the development and prognosis of follicular cell-derived thyroid tumours.

Monika Migdalska-Sęk, Dorota Pastuszak-Lewandoska, Ewa Brzeziańska

Department of Molecular Bases of Medicine, Medical University of Lodz, ul. Pomorska 251, 92-213 Łódź, Poland. migdalska5@wp.pl

Endokrynologia Polska 2012

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Microsatellite instability (MSI) and loss of heterozygosity (LOH) represent molecular disorders acquired by the cell during neoplastic transformation. Both are associated with genetic instability. Functional silencing of tumour suppressor genes may be the consequence of genomic instability, particularly of the globally occurring LOH phenomenon. Numerous studies have confirmed the role of MSI/LOH at both the early and the late stages of thyroid tumourigenesis. This paper reviews the available study results on MSI/LOH significance and prevalence in thyroid neoplasms. Additionally, it summarises the knowledge regarding the practical usage of the study findings on MSI/LOH in aspects of cancer risk assessment as well as the development of prognostic markers for thyroid neoplasms.

Citation

Monika Migdalska-Sęk, Dorota Pastuszak-Lewandoska, Ewa Brzeziańska. MSI and LOH in the development and prognosis of follicular cell-derived thyroid tumours. Endokrynologia Polska. 2012;63(2):126-36