Neutrophil recruitment is inhibited by nicotinamide in experimental pleurisy in mice.

Raphael G Ferreira, Tamires C Matsui, Adriana M Godin, Lindisley F Gomides, Pedro E M Pereira-Silva, Igor D G Duarte, Gustavo B Menezes, Márcio M Coelho, André Klein

Laboratório de Inflamação e Dor - Instituto de Ciências Biológicas, UFMG, Brazil.

European journal of pharmacology 2012 Jun 15

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Several emerging lines of evidence support an anti-inflammatory role for nicotinamide and other vitamin B components. However, the mechanisms underlying their activity remain unclear. In the present study, we investigated the ability of nicotinamide to inhibit both neutrophil recruitment in IL-8-, LTB(4)- or carrageenan-induced pleurisy in mice and the rolling and adherence of neutrophils. Nicotinamide inhibited IL-8-, LTB(4)- and carrageenan-induced neutrophil migration, KC production and carrageenan-induced neutrophil rolling and adherence. We propose that the effects of nicotinamide in inhibiting neutrophil recruitment in carrageenan-induced pleurisy may be due to the ability of nicotinamide to inhibit the action of IL-8 and LTB(4), decrease KC production, and inhibit early events that regulate leukocyte migration from blood vessels into tissue. Copyright © 2012 Elsevier B.V. All rights reserved.

Citation

Raphael G Ferreira, Tamires C Matsui, Adriana M Godin, Lindisley F Gomides, Pedro E M Pereira-Silva, Igor D G Duarte, Gustavo B Menezes, Márcio M Coelho, André Klein. Neutrophil recruitment is inhibited by nicotinamide in experimental pleurisy in mice. European journal of pharmacology. 2012 Jun 15;685(1-3):198-204