Lipoxin receptor agonist, may be a potential treatment for hemorrhagic shock-induced acute lung injury.

Jie Gong, Hong-Bin Li, Si Guo, You Shang, Shang-Long Yao

Department of Anaesthesiology and Critical Care, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Medical hypotheses 2012 Jul

filter terms:

The main pathogenesis of acute lung injury induced by hemorrhagic shock is increasingly recognized as an inflammatory process. BML-111, a lipoxin receptor agonist, has been demonstrated to promote acute inflammatory resolution by reduction of pro-inflammatory cytokines, attenuation of neutrophilic infiltration, and increasing macrophage phagocytosis of apoptotic neutrophils. Meanwhile, lipoxins and lipoxin analogues have been reported to play pro-resolving and anti-inflammatory effects in many disease models including cerebral ischemia, dorsal air pouch, peritonitis, and so on. Therefore, we hypothesize that BML-111 may be implicated in pathogenesis of hemorrhagic shock-induced acute lung injury. Copyright © 2012 Elsevier Ltd. All rights reserved.

Citation

Jie Gong, Hong-Bin Li, Si Guo, You Shang, Shang-Long Yao. Lipoxin receptor agonist, may be a potential treatment for hemorrhagic shock-induced acute lung injury. Medical hypotheses. 2012 Jul;79(1):92-4