A new cyclododeca[d]oxazole derivative from Streptomyces spp. CIBYL1.

Xiang Pu, Guangzhou Li, Tao Yang, Guoyou Li, Jinhai Yi, Guolin Zhang, Yinggang Luo

Center for Natural Products Research , Chengdu Institute of Biology of the Chinese Academy of Sciences, Chengdu, People's Republic of China.

Natural product research 2013 Apr

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A novel secondary metabolite, N-trans-cinnamoyl 2-amino-3a,4,5,6,7,8,9,10,11,12,13,13a-dodecahydrocyclododeca[d]oxazole (1), was isolated from Streptomyces spp. CIBYL1, along with five known compounds, pimprinine (2), (3R,4S,5R,6R)-3,4,5,6-tetrahydro-4-hydroxy-3,5,6-trimethyl-2H-pyran-2-one (3), indolyl-3-carboxylic acid (4), 2-phenylacetamide (5) and di(1H-pyrrol-2-yl)methanone (6). The structures of these metabolites were elucidated on the basis of extensive analysis of spectroscopic data, including OR, IR, HRMS, 1D and 2D NMR data and chemical derivation.

Citation

Xiang Pu, Guangzhou Li, Tao Yang, Guoyou Li, Jinhai Yi, Guolin Zhang, Yinggang Luo. A new cyclododeca[d]oxazole derivative from Streptomyces spp. CIBYL1. Natural product research. 2013 Apr;27(7):603-8