Epigenetic regulation of osteoclastogenesis by histone modification].

Yasunori Omata, Sakae Tanaka

Clinical calcium 2012 May

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Osteoclasts are multinuclear fusion cells derived from monocyte and macropharge lineage cells, which are differentiated in the presence of M-CSF and RANKL. Some transcription factors, such as NFATc1, are known to be associated with osteoclastogenesis however, the epigenetic regulation is not uncovered. Recently it was revealed that the activation and the repression of gene in the ES cells were strictly regulated by the histone modification, such as H3K4/H3K27 trimethylation mark. In this section we review the epigenetic regulation by histone modification and the role in osteoclastogenesis.