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miRNAs in cartilage development].
Department of Systems BioMedicine, Tokyo Medical and Dental University, Japan.
Clinical calcium 2012 MaySizes of these terms reflect their relevance to your search.
MicroRNAs (miRs) are - 22 nucleotide non-cording forms of RNA and exhibit tissue or developmental stage specific expression patterns. Recent findings show taht the expression of miR-140, which is specifically expressed in chondrocytes, is reduced in OA chondrocytes. Furthermore, knockdown of miR-140 in mice chondrocytes promotes arthritis in mice. In addition to this, several other miRs have also been shown to play important roles in chondrocytes. Thus, miRs should be critical factors for cartilage development and homeostasis.
Citation
Hiroshi Asahara. miRNAs in cartilage development]. Clinical calcium. 2012 May;22(5):653-7
PMID: 22549189
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