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An improved synthesis of DNA-dependent protein kinase inhibitor, IC86621 is described. This developed method provides an easy access to this simple molecule by using amination, acetylation and Fries rearrangement reactions.


Girish Chandra, Varughese Alexander, Hyuk Woo Lee, Lak Shin Jeong. Improved synthesis of a DNA-dependent protein kinase inhibitor IC86621. Archives of pharmacal research. 2012 Mar;35(4):639-45

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PMID: 22553056

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