Endothelin-1 and adrenomedullin plasma levels after exposure to fludrocortisone, dexamethasone, and spironolactone.

Sarah Vogt, Elena Winkler, Derik Hermsen, Matthias Schott, Sven Schinner, Werner A Scherbaum, Holger S Willenberg

Department of Endocrinology, Diabetes and Rheumatology, University Hospital Duesseldorf, Duesseldorf, Germany.

Clinical and experimental hypertension (New York, N.Y. : 1993) 2012

filter terms:

We asked whether plasma concentrations of endothelin-1 (ET-1) or adrenomedullin (ADM) are altered by different activity states of the renin-angiotensin-aldosterone system (RAAS). Levels of ET-1 and ADM were studied in patients with primary aldosteronism (n = 15), essential hypertension (n = 15), and adrenal insufficiency (n = 7). Effects of fludrocortisone, dexamethasone, or spironolactone treatment on ET-1 and ADM levels were also analyzed. Plasma ET-1 and ADM concentrations did not differ significantly between the patient groups. After fludrocortisone, dexamethasone, or spironolactone treatment, both ET-1 and ADM did not change significantly. The data support the hypothesis that the RAAS is not directly linked with the ET-1/ADM system.

Citation

Sarah Vogt, Elena Winkler, Derik Hermsen, Matthias Schott, Sven Schinner, Werner A Scherbaum, Holger S Willenberg. Endothelin-1 and adrenomedullin plasma levels after exposure to fludrocortisone, dexamethasone, and spironolactone. Clinical and experimental hypertension (New York, N.Y. : 1993). 2012;34(8):582-7