mGlu3 receptor and astrocytes: partners in neuroprotection.

Daniela Durand, Lila Carniglia, Carla Caruso, Mercedes Lasaga

Instituto de Investigaciones Biomédicas (INBIOMED), School of Medicine, University of Buenos Aires, Paraguay 2155 Piso 10, CABA 1121 Buenos Aires, Argentina. ddurand@fmed.uba.ar

Neuropharmacology 2013 Mar

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Astrocytes are currently studied intensively because of their now highlighted relevance as key players with neurons that modulate a wide range of central functions, from synaptic plasticity and synaptogenesis to regulation of metabolic and neuroinflammatory processes. Since the discovery of mGlu3 receptors on astrocytes, accumulating evidence supports a role of these receptors not only in maintaining synaptic homeostasis and treating psychiatric disorders but also in promoting astrocyte survival in several pathologic conditions. This review focuses on providing up-to-date knowledge regarding effects of activating astroglial mGlu3 receptors on psychiatric disorders, astrocyte and neuronal survival, and neurodegenerative diseases. This article is part of a Special Issue entitled 'Metabotropic Glutamate Receptors'. Copyright © 2012 Elsevier Ltd. All rights reserved.

Citation

Daniela Durand, Lila Carniglia, Carla Caruso, Mercedes Lasaga. mGlu3 receptor and astrocytes: partners in neuroprotection. Neuropharmacology. 2013 Mar;66:1-11