Surface modification of magnesium alloys developed for bioabsorbable orthopedic implants: a general review.

Jiali Wang, Jian Tang, Peng Zhang, Yangde Li, Jue Wang, Yuxiao Lai, Ling Qin

Center for Translational Medicine Research and Development, Institute of Biomedical and Health Engineering, Chinese Academy of Sciences, Shenzhen, China. jl.wang@siat.ac.cn

Journal of biomedical materials research. Part B, Applied biomaterials 2012 Aug

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As a bioabsorbable metal with mechanical properties close to bone, pure magnesium or its alloys have great potential to be developed as medical implants for clinical applications. However, great efforts should be made to avoid its fast degradation in vivo for orthopedic applications when used for fracture fixation. Therefore, how to decease degradation rate of pure magnesium or its alloys is one of the focuses in Research and Development (R&D) of medical implants. It has been recognized that surface modification is an effective method to prevent its initial degradation in vivo to maintain its desired mechanical strength. This article reviews the recent progress in surface modifications for prevention of fast degradation of magnesium or its alloys using in vitro testing model, a fast yet relevant model before moving towards time-consuming and expensive in vivo testing. Pros and cons of various surface modifications are also discussed for the goal to design available products to be applied in clinical trials. Copyright © 2012 Wiley Periodicals, Inc.

Citation

Jiali Wang, Jian Tang, Peng Zhang, Yangde Li, Jue Wang, Yuxiao Lai, Ling Qin. Surface modification of magnesium alloys developed for bioabsorbable orthopedic implants: a general review. Journal of biomedical materials research. Part B, Applied biomaterials. 2012 Aug;100(6):1691-701