Changes in carotid artery sonogram in premature adrenarche.

Premature adrenarche (PA), the appearance of pubic hair before the age of 8 years in girls and before 9 years in boys, may predict future morbidity, such as metabolic syndrome (MS). The purpose of this study is to assess carotid artery ultrasound changes in children with PA. PA children were matched with a group of prepubertal controls without PA. Subjects and controls underwent clinical and biochemical evaluation and sonograms of the carotid arteries. Twelve children with PA and their matched controls were studied. Carotid artery ultrasonography showed elevation of the inner and outer diameter of the left carotid, and the cross-sectional area of the lumen and outer wall, and the outer diameter of the right carotid artery in PA. However, none of the above results maintained statistical significance when a Hochberg correction was applied. Carotid artery diameter and cross-sectional area may be useful non-invasive markers of vascular pathology and MS in premature pubarche.

Citation

Revi P Mathew, Marta Hernanz-Schulman, Wenli Wang, Benjamin Saville, Andrew Bremer. Changes in carotid artery sonogram in premature adrenarche. Journal of pediatric endocrinology & metabolism : JPEM. 2012;25(1-2):139-45

Mesh Tags

PMID: 22570963

search → result