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A charge-frustrated amphiphile composed of a pyrene-1,3,6-trisulfonate head group and an eicosane side chain can be used as a fluorescence chemosensor for spermine. The sensor allows the detection of spermine down to the nanomolar concentration range with good selectivity over closely related biogenic amines such as spermidine.


Ziya Köstereli, Kay Severin. Fluorescence sensing of spermine with a frustrated amphiphile. Chemical communications (Cambridge, England). 2012 Jun 14;48(47):5841-3

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PMID: 22573305

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