Gelsemium alkaloids, immunosuppressive agents from Gelsemium elegans.

You-Kai Xu, Shang-Gao Liao, Zhi Na, Hua-Bin Hu, Yan Li, Huai-Rong Luo

CAS Key Laboratory of Tropical Forest Ecology, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Mengla, Yunnan Province, PR China. xyk@xtbg.ac.cn

Fitoterapia 2012 Sep

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Bioassay-guided isolation of the stems of Gelsemium elegans has led to the isolation of two new Gelsemium alkaloids, 21-(2-oxopropyl)-koumine (1) and 11-methoxygelselegine (2), and two known alkaloids, koumine (3) and gelselegine (4). The structures of 1-2 were determined by spectroscopic (for both) and single-crystal X-ray diffraction (for 1) analysis. All compounds isolated were evaluated for their potential as immunosuppressive agents and the data suggested that Gelsemium alkaloids of different structural types possibly have potential as immunosuppressive agents. Copyright © 2012 Elsevier B.V. All rights reserved.

Citation

You-Kai Xu, Shang-Gao Liao, Zhi Na, Hua-Bin Hu, Yan Li, Huai-Rong Luo. Gelsemium alkaloids, immunosuppressive agents from Gelsemium elegans. Fitoterapia. 2012 Sep;83(6):1120-4