Cervical ripening at term. A randomized and prospective study: Misoprotol versus dinoprostone].

To compare the efficacy and safety of cervical ripening at term by vaginal Misoprostol and Dinoprostone. We performed a prospective randomized study on cervical ripening with misoprostol and dinoprostone in the third trimester of pregnancy. 300 patients have been divided into two groups: one consisted by 150 patients who received Misoprostol (Cytotec ®) and the second consisted by 150 patients who received Dinoprostone (Prépidil ®). Analysis of our results allowed to reveal: a significant decrease in the time of entry into work for the Misoprostol group (9.08 hours versus 12.51 hours, p = 0.007), a significant reduction delivery time (14.48 hours versus 19.30 hours, p = 0.001). Moreover, the birth rate in the first 24 hours after the first dose was significantly higher in the Misoprostol group (86.7% versus 72.7%, p = 0.003). The use of oxytocin was significantly reduced with Misoprostol (44% versus 58.7%, p = 0.01). The mode of delivery was not influenced by membership in one or other of the two groups. Misoprostol seems an interesting molecule for cervical ripening and labor induction.

Citation

Haikel Trabelsi, Nabil Mathlouthi, Sonia Zayen, Mohamed Dhouib, Kaies Chaabene, Khaled Trabelsi, Habib Amouri, Belhassen Ben Ayed, Mohamed Guermazi. Cervical ripening at term. A randomized and prospective study: Misoprotol versus dinoprostone]. La Tunisie médicale. 2012 May;90(5):362-9

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PMID: 22585642

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