Sensitive fluorescence biosensor for folate receptor based on terminal protection of small-molecule-linked DNA.

Xiaofeng Wei, Wenlie Lin, Na Ma, Fang Luo, Zhenyu Lin, Longhua Guo, Bin Qiu, Guonan Chen

Ministry of Education Key Laboratory of Analysis and Detection Technology for Food Safety (Fuzhou University), Department of Chemistry, Fuzhou University, Fuzhou, 350002, China.

Chemical communications (Cambridge, England) 2012 Jun 21

filter terms:

Based on the specific folic acid-folate receptor (FA-FR) interaction, macromolecular FR can bind with FA-linked DNA-small molecule chimeras, which can prevent enzymolysis by exonuclease III (Exo III), enabling a novel fluorescence biosensor for FR to be developed using quinaldine red as a G-quadruplex-binding probe.

Citation

Xiaofeng Wei, Wenlie Lin, Na Ma, Fang Luo, Zhenyu Lin, Longhua Guo, Bin Qiu, Guonan Chen. Sensitive fluorescence biosensor for folate receptor based on terminal protection of small-molecule-linked DNA. Chemical communications (Cambridge, England). 2012 Jun 21;48(49):6184-6