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There are discrepancies in the retrospective studies published in literature of whether or not bacteraemia could lead to false positivity of 1,3-β-D (BG) glucan assay. We performed, for the first time, a prospective study evaluating the role of bacterial bloodstream infection to the reactivity of BG assay. Twenty-six episodes of bacteraemia that occurred in high-risk haematological patients were included in our study. Consecutive BG levels >80 pg ml(-1) were required for test positivity. Only 2 of 26 patients were BG positive - both with IFDs. Thus, we prospectively did not prove bacteraemia as the source of cross reactivity of BG assay in haematological patients. © 2012 Blackwell Verlag GmbH.

Citation

Zdenek Racil, Iva Kocmanova, Martina Toskova, Jana Winterova, Martina Lengerova, Shira Timilsina, Jiri Mayer. Reactivity of the 1,3-β-D-glucan assay during bacteraemia: limited evidence from a prospective study. Mycoses. 2013 Mar;56(2):101-4

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PMID: 22594314

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