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5,10,15,20-Tetrakis(3-hydroxyphenyl)chlorin (mTHPC, Temoporfin) is a widely investigated second generation photosensitizer. Its initial use in solution form (Foscan®) is now complemented by nanoformulations (Fospeg®, Foslip®) and new chemical derivatives related to the basic hydroxyphenylporphyrin framework. Advances in formulation, chemical modifications and targeting strategies open the way for third generation photosensitizers and give an illustrative example for the developmental process of new photoactive drugs. Copyright © 2011 Elsevier B.V. All rights reserved.


Mathias O Senge. mTHPC--a drug on its way from second to third generation photosensitizer? Photodiagnosis and photodynamic therapy. 2012 Jun;9(2):170-9

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PMID: 22594988

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