Clinical characteristics and corticosteroid treatment of acute eosinophilic pneumonia.

Chin Kook Rhee, Kyung Hoon Min, Nam Yeol Yim, Ji Eun Lee, Na Rae Lee, Man Pyo Chung, Kyeongman Jeon

Dept of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, Catholic University of Korea, Seoul, Korea.

The European respiratory journal 2013 Feb

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The clinical characteristics and optimal duration of corticosteroid treatment for acute eosinophilic pneumonia (AEP) have not been fully evaluated. This was a retrospective study of prospectively collected data from 137 patients with AEP, treated with standardised protocol, to clarify the clinical characteristics and compare the efficacies of 2 weeks versus 4 weeks of corticosteroid treatment for AEP. The majority of the patients altered their smoking habits within a median (interquartile range) of 17 (13-26) days prior to development of AEP. 80 (58%) patients presented with acute respiratory failure. A total of 127 (92%) patients were treated with corticosteroids: 4 weeks, n=42; 2 weeks, n=85. Major symptoms were resolved in 3 days and the severity of respiratory failure was inversely correlated with clinical outcomes. After adjusting for differences in baseline characteristics between the groups, the differences in adjusted mean (95% confidence interval) for resolution of dyspnoea and disappearance of all symptoms were 0.57 (-0.71-1.86) and -0.04 (-1.91-1.83) days, respectively. The difference in adjusted proportion of resolution of radiological abnormalities was 6.92% (-8.19-22.02). In conclusion, the duration of corticosteroid treatment could be shortened to 2 weeks, even in patients with respiratory failure.

Citation

Chin Kook Rhee, Kyung Hoon Min, Nam Yeol Yim, Ji Eun Lee, Na Rae Lee, Man Pyo Chung, Kyeongman Jeon. Clinical characteristics and corticosteroid treatment of acute eosinophilic pneumonia. The European respiratory journal. 2013 Feb;41(2):402-9