Manual microdissection technique in a case of subcutaneous panniculitis-like T-cell lymphoma: a case report and review.

Demonstration of T-cell receptor gene monoclonality often plays an important role in the diagnosis of T-cell lymphoma. When a test to detect monoclonality is performed on whole tissue sections, the presence of a reactive lymphocyte population may reduce sensitivity. This may be especially true for early or borderline cases of lymphoma. Microdissection techniques may be utilized to more readily identify a clonal population of lymphocytes. Subcutaneous panniculitis-like T-cell lymphoma represents a cutaneous lymphoid neoplasm whose clinical course may vary from an indolent, waxing and waning course to an aggressive course resulting in death. We report the first case of a microdissection technique used to facilitate diagnosing a case of subcutaneous panniculitis-like T-cell lympoma. Copyright © 2012 John Wiley & Sons A/S.

Citation

Daniel Hoffman, Marsha Chaffins, Milena Cankovic, Koichi Maeda, Shane Meehan. Manual microdissection technique in a case of subcutaneous panniculitis-like T-cell lymphoma: a case report and review. Journal of cutaneous pathology. 2012 Aug;39(8):769-72

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PMID: 22612348

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