A short, high yielding protocol has been developed for the enantioselective and general synthesis of C2-functionalized, benzyl protected morpholines and orthogonally N,N'-protected piperazines from a common intermediate.
Matthew C O'Reilly, Craig W Lindsley. A general, enantioselective synthesis of protected morpholines and piperazines. Organic letters. 2012 Jun 01;14(11):2910-3
PMID: 22616979
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