Replication of minute virus of mice in murine cells is facilitated by virally induced depletion of p21.

Richard O Adeyemi, David J Pintel

Journal of virology 2012 Aug

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The DNA damage response to infection with minute virus of mice (MVM) leads to activated p53; however, p21 levels are reduced via a proteasome-mediated mechanism. This loss was sustained, as virus replicated in infected cells held at the G(2)/M border. Addition of the cyclin-dependent kinase (CDK) inhibitor roscovitine after S-phase entry reduced MVM replication, suggesting that CDK activity was critical for continued viral replication and virus-induced reduction of p21 may thus be necessary to prevent inhibition of CDK.

Citation

Richard O Adeyemi, David J Pintel. Replication of minute virus of mice in murine cells is facilitated by virally induced depletion of p21. Journal of virology. 2012 Aug;86(15):8328-32