State and trait markers of emotionally charged visual event-related potentials (P300) in drug-naïve schizophrenia.

Keiichiro Mori, Kiichiro Morita, Yoshihisa Shoji, Toshimasa Matsuoka, Ryo Fujiki, Naohisa Uchimura

Department of Neuropsychiatry, Kurume University School of Medicine, Kurume, Japan.

Psychiatry and clinical neurosciences 2012 Jun

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In the present study, we investigated the changes in P3 component in the emotionally charged visual event-related potentials (ERP) in 30 drug-naïve schizophrenic patients for up to 1 year. Visual oddball event-related potential was recorded from six recording sites for crying baby or smiling baby photographs. ERP were recorded before the treatment (session 1 [S1]), after 3 months (session 2 [S2]), and after 12 months (session 3 [S3]), as well as in 30 healthy subjects. Before taking medicine, there were no significant differences in the P300 amplitude between viewing photographs of a crying and a smiling baby. The P300 amplitude was significantly larger at S2 and S3 than at S1 for a crying baby, while there was no significant difference among sessions for a smiling baby after medication. A significant difference of the P300 amplitude was only observed between S3 and healthy subjects for a smiling baby. The P300 latency only when viewing a smiling face became significantly longer at S3 than those at S1 and S2. A significant negative correlation was obtained between the P300 amplitude changes upon viewing crying faces and negative syndrome score changes at the Pz site. The P300 amplitude induced by crying-face stimuli may be a state marker and the P300 amplitude caused by smiling-face stimuli may be a trait marker during recovery in schizophrenic patients. Atypical antipsychotic medications may be useful and may recover cognitive function reflected by the emotionally charged visual P300 components in schizophrenic patients. © 2012 The Authors. Psychiatry and Clinical Neurosciences © 2012 Japanese Society of Psychiatry and Neurology.

Citation

Keiichiro Mori, Kiichiro Morita, Yoshihisa Shoji, Toshimasa Matsuoka, Ryo Fujiki, Naohisa Uchimura. State and trait markers of emotionally charged visual event-related potentials (P300) in drug-naïve schizophrenia. Psychiatry and clinical neurosciences. 2012 Jun;66(4):261-9