Covalent attachment of antagonists to the α7 nicotinic acetylcholine receptor: synthesis and reactivity of substituted maleimides.

Joseph I Ambrus, Jill I Halliday, Nicholas Kanizaj, Nathan Absalom, Kasper Harpsøe, Thomas Balle, Mary Chebib, Malcolm D McLeod

Research School of Chemistry, Australian National University, Canberra, ACT 0200, Australia.

Chemical communications (Cambridge, England) 2012 Jul 7

filter terms:

The 3-methylmaleimide congeners of the natural product methyllycaconitine (MLA) and an analogue covalently attach to functional cysteine mutants of the α7 nicotinic acetylcholine receptor (nAChR).

Citation

Joseph I Ambrus, Jill I Halliday, Nicholas Kanizaj, Nathan Absalom, Kasper Harpsøe, Thomas Balle, Mary Chebib, Malcolm D McLeod. Covalent attachment of antagonists to the α7 nicotinic acetylcholine receptor: synthesis and reactivity of substituted maleimides. Chemical communications (Cambridge, England). 2012 Jul 7;48(53):6699-701