A heme degradation enzyme, HutZ, from Vibrio cholerae.

Takeshi Uchida, Yukari Sekine, Toshitaka Matsui, Masao Ikeda-Saito, Koichiro Ishimori

Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo 060-0810, Japan. uchida@sci.hokudai.ac.jp

Chemical communications (Cambridge, England) 2012 Jul 7

filter terms:

HutZ, one of the crucial proteins of the iron uptake system in Vibrio cholerae, was purified, which binds to heme at a stoichiometry of 1 : 1. In the presence of ascorbic acid, the HutZ-bound heme degrades via the same intermediates observed in heme oxygenase, suggesting that HutZ works as a heme degradation enzyme.

Citation

Takeshi Uchida, Yukari Sekine, Toshitaka Matsui, Masao Ikeda-Saito, Koichiro Ishimori. A heme degradation enzyme, HutZ, from Vibrio cholerae. Chemical communications (Cambridge, England). 2012 Jul 7;48(53):6741-3