The influence of N-[imino(1-piperidinyl)methyl]guanidine and N-[imino(4-morpholinyl)methyl]guanidine on citrate content, aconitase and citrate synthase activities at ischemia-reperfusion of rats brain].

O V Sukhoveeva, T N Popova, A V Makeeva, I Iu Iskusnykh

Biomedit͡sinskai͡a khimii͡a 2011 Sep-Oct

filter terms:

The influence of some guanidine derivatives on the level of brain citrate, brain activities of aconitase and citrate synthase has been investigated in rats subjected to ischemia-reperfusion. Administration of N-[imino(1-piperidinyl)methyl]guanidine and N-[imino(4-morpholinyl)methyl]guanidine resulted in changes of specific activities of aconitase and citrate synthase towards control values. Under these conditions the citrate level considerably decreased versus rats with untreated ishemia-reperfusion. Treatment with these compounds also decreased the degree of DNA fragmentation markedly increased in rats with ischemia-reperfusion.

Citation

O V Sukhoveeva, T N Popova, A V Makeeva, I Iu Iskusnykh. The influence of N-[imino(1-piperidinyl)methyl]guanidine and N-[imino(4-morpholinyl)methyl]guanidine on citrate content, aconitase and citrate synthase activities at ischemia-reperfusion of rats brain]. Biomedit͡sinskai͡a khimii͡a. 2011 Sep-Oct;57(5):519-25