Markedly disturbed sleep in medically refractory compared to controlled epilepsy - a clinical and polysomnography study.

Paresh Zanzmera, Garima Shukla, Anupama Gupta, Hariom Singh, Vinay Goyal, Achal Srivastava, Madhuri Behari

Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.

Seizure : the journal of the British Epilepsy Association 2012 Sep

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To evaluate sleep disturbances or sleep related events and their characteristics among patients with medically refractory epilepsy, compared to those with controlled epilepsy. In a prospective case-controlled study, patients of medically refractory and controlled epilepsy were recruited and history pertaining to epilepsy and sleep related events and Epworth sleepiness scores were recorded and all patients underwent over night polysomnography. Among 40 patients, 20 with medically refractory (Group 1) and 20 with controlled epilepsy (Group 2) (median age 18, range 10-35 years), the self reported sleep parameters in Group 1 patients were found to be significantly different as compared to Group 2, in terms of the duration of night time sleep, day time sleep, day time nap frequency, total sleep hours per day, excessive daytime sleepiness (EDS)(45% vs. 15%) and average sleep hours over the week prior to polysomnography. On PSG, Group 1 patients showed significantly less total sleep time [340.4 min (147-673) vs. 450.3 min (330-570)] with delayed sleep latency and REM latency, poor sleep efficiency [80.45 (40.5-98.0) vs. 95.45 (88.4-99.7)] and frequent arousals and wake after sleep onset (WASO) compared to Group 2 patients. Four patients (20%) in Group 1 compared to none in Group 2 were found to have mild obstructive sleep apnea. Our results indicate that medically refractory epilepsy patients believe that they spend more time sleeping, in contrast to the documented shorter sleep duration on polysomnography. This difference between perceived and actual sleep seems, by their data, to arise mainly from sleep fragmentation, disturbed architecture and the interesting finding of associated sleep apnea among the medically refractory epilepsy patients. Copyright © 2012 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.

Citation

Paresh Zanzmera, Garima Shukla, Anupama Gupta, Hariom Singh, Vinay Goyal, Achal Srivastava, Madhuri Behari. Markedly disturbed sleep in medically refractory compared to controlled epilepsy - a clinical and polysomnography study. Seizure : the journal of the British Epilepsy Association. 2012 Sep;21(7):487-90