PABPN1 shuts down alternative poly(A) sites.

mRNA Regulation and Development, Institute of Human Genetics, CNRS UPR1142, Montpellier Cedex 5, France. Martine.Simonelig@igh.cnrs.fr

Cell research 2012 Oct

Although overlooked for many years, alternative cleavage and polyadenylation (APA) is now emerging as a major mechanism of gene regulation. A recent study identifies poly(A)-binding protein nuclear 1 (PABPN1), a general factor of polyadenylation, as a suppressor of alternative poly(A) sites.