Bioactive briarane diterpenoids from the South China Sea gorgonian Dichotella gemmacea.

Cui Li, Ming-Ping La, Hua Tang, Wei-Hua Pan, Peng Sun, Karsten Krohn, Yang-Hua Yi, Ling Li, Wen Zhang

Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433, PR China.

Bioorganic & medicinal chemistry letters 2012 Jul 1

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Six new briarane diterpenoids, gemmacolides T-Y (1-6), were isolated together with three known analogs, juncenolide J (7), praelolide (8), and junceellolide C (9), from the South China Sea gorgonian Dichotella gemmacea. The structures of the new compounds were elucidated by detailed spectroscopic analysis and comparison with reported data. The absolute configuration was suggested based on biosynthetic considerations. In an in vitro bioassay, compounds 3 and 6 showed potent growth inhibition towards tumor cell lines of A549 and MG63, being stronger than the positive control of adriamycin. These compounds also exhibited weak antimicrobial activity against the bacterium Escherichia coli and the fungi Microbotryum violaceum and Septoria tritici. Copyright © 2012 Elsevier Ltd. All rights reserved.

Citation

Cui Li, Ming-Ping La, Hua Tang, Wei-Hua Pan, Peng Sun, Karsten Krohn, Yang-Hua Yi, Ling Li, Wen Zhang. Bioactive briarane diterpenoids from the South China Sea gorgonian Dichotella gemmacea. Bioorganic & medicinal chemistry letters. 2012 Jul 1;22(13):4368-72