Correlation Engine 2.0
Clear Search sequence regions

Sizes of these terms reflect their relevance to your search.

The globus pallidus (GP) plays a key role in the overall basal ganglia (BG) activity. Despite evidence of cholinergic inputs to GP, their role in the spiking activity of GP neurons has not received attention. We examine the effect of local activation and blockade of muscarinic receptors (MRs) in the spontaneous firing of GP neurons both in normal and ipsilateral striatum-lesioned rats. We found that activation of MRs produces heterogeneous responses in both normal and ipsilateral striatum-lesioned rats: in normal rats the response evoked by MRs depends on the predrug basal firing rate; the inhibition evoked by MRs is higher in normal rats than in striatum-lesioned rats; the number of neurons that undergo inhibition is lower in striatum-lesioned rats than in normal rats. Our data suggest that modulation of MRs in the GP depends on the firing rate before their activation and on the integrity of the striato-pallidal pathway.


Enrique Querejeta, Alberto Alatorre, Alain Ríos, Rafael Barrientos, Aldo Oviedo-Chávez, Rosa Amalia Bobadilla-Lugo, Alfonso Delgado. Striatal input- and rate-dependent effects of muscarinic receptors on pallidal firing. TheScientificWorldJournal. 2012;2012:547638

Expand section icon Mesh Tags

Expand section icon Substances

PMID: 22654627

View Full Text