Risks and untoward toxicities of antibody-based immunoconjugates.

Department of Molecular Microbiology and Biotechnology, The George S. Wise Faculty of Life Sciences, Tel-Aviv University, Ramat Aviv 69978, Israel.

Advanced drug delivery reviews 2012 Dec

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Antibody-based immunoconjugates are specifically targeted monoclonal antibodies that deliver a cytotoxic payload to their target. The cytotoxic agents can be highly potent drugs, radionuclides or toxins. Such molecules, referred to as antibody-drug conjugates, radioimmunoconjugates and immunotoxins, respectively, represent a promising approach for enhancing the efficacy of unconjugated (naked) antibodies for improved therapeutic results. Though tremendous progress has been achieved over the last few decades, the safety of these molecules still remains a matter of concern and a careful design is required for achieving a relatively safe toxicity profile along with therapeutic effectiveness. This review focuses on the toxicities arising from the use of these potent agents. Copyright © 2012 Elsevier B.V. All rights reserved.

Citation

Dana Litvak-Greenfeld, Itai Benhar. Risks and untoward toxicities of antibody-based immunoconjugates. Advanced drug delivery reviews. 2012 Dec;64(15):1782-99