Bioinformatic research of the family of PEX11, peroxisome proliferous factor in fungus].

The family members of PEX11 are key factors involved in regulation of peroxisome proliferation. Sixty-six PEX11p candidates of PEX11 gene family from 26 representative fungal species were obtained and analyzed by bioinformatic strategies. In most filamentous fungi, 2 or 3 potential PEX11ps were found, in contrast with 1 or 2 in yeast species. Compared with other fungal species, the Ascomycetes tend to have more PEX11ps, and even 5 in several individuals. The data of phylogenetic analysis and protein structure indicated that all of the PEX11ps were divided into 3 groups: I, II, and III. The members of group I and group III existed in most species, while those in group II were found only in Pezizomycotina. By MEME analysis, 5-6 conserved motifs were found in each PEX11ps. Among them,motif 8 in C-terminal had the most conservation, indicating that this motif probably plays a key role in maintaining the proper function of PEX11p.

Citation

Xin Zhang, Hua Jiang, Yan-Li Wang, Zhen Zhang, Xue-Qin Mao, Rong-Yao Chai, Hai-Ping Qiu, Xin-Fa Du, Jiao-Yu Wang, Guo-Chang Sun. Bioinformatic research of the family of PEX11, peroxisome proliferous factor in fungus]. Yi chuan = Hereditas / Zhongguo yi chuan xue hui bian ji. 2012 May;34(5):635-46

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PMID: 22659436

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