Hyaluronan-chondroitin hybrid oligosaccharides as new life science research tools.

Ikuko Kakizaki, Shinichiro Suto, Yota Tatara, Toshiya Nakamura, Masahiko Endo

Department of Glycotechnology, Center for Advanced Medical Research, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562, Japan. kaki@cc.hirosaki-u.ac.jp

Biochemical and biophysical research communications 2012 Jun 29

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Hyaluronan and chondroitin are glycosaminoglycans well-known as components of pharmaceutical agents and health foods. From these attractive molecules, using transglycosylation reaction of testicular hyaluronidase, we synthesized hybrid neo-oligosaccharides not found in nature. We also found a new site between the chondroitin disaccharide unit and hyaluronan disaccharide unit recognized by a hyaluronan lyase specific to hyaluronan using these hybrid oligosaccharides as substrates. We hope that these hybrid oligosaccharides will help to elucidate the involvement of hyaluronan, chondroitin, and chondroitin sulfates in the mechanisms of cell functions and diseases, based on the structures of these glycosaminoglycans. Copyright © 2012 Elsevier Inc. All rights reserved.

Citation

Ikuko Kakizaki, Shinichiro Suto, Yota Tatara, Toshiya Nakamura, Masahiko Endo. Hyaluronan-chondroitin hybrid oligosaccharides as new life science research tools. Biochemical and biophysical research communications. 2012 Jun 29;423(2):344-9