Aggressive clinical course of primary invasive vaginal carcinoma associated with type 61 HPV: a case report.

Valentina Zanfagnin, Elisa Tripodi, Stefania Perotto, Nicoletta Ravarino, Paolo Zola

Department of Obstetrics and Gynecology, and 2Department of Pathology, Mauriziano Umberto I Hospital, Turin, Italy. valentina.zanfagnin@gmail.com

Tumori 2012 Mar-Apr

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Primary invasive vaginal cancer is one of the rarest malignant processes in the female genital tract. The etiology has not been identified, but the strongest association is with HPV infection and subtypes 16 and 18 have the highest oncogenic potential. We present the case of a young woman diagnosed with metastatic squamous cell carcinoma of the vagina associated with HPV type 61, a non-oncogenic HPV type. We report the propensity of a primary vaginal neoplasm to spread to lymphatic vessels early and the unresponsive aggressive behavior to multimodal therapy.

Citation

Valentina Zanfagnin, Elisa Tripodi, Stefania Perotto, Nicoletta Ravarino, Paolo Zola. Aggressive clinical course of primary invasive vaginal carcinoma associated with type 61 HPV: a case report. Tumori. 2012 Mar-Apr;98(2):57e-58e