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Choline-positive neuroprotectors citicoline and choline alfoscerate decreased blood concentration of protein S100 in clinical trial on 52 patients in the first days after acute ischemic stroke. Neuroprotective therapy has also produced stabilization of blood-brain barrier.

Citation

O E Vaizova, N A Zautner, V M Alifirova, A I VengerovskiÄ­. Influence of neuroprotectors with choline-positive action on the level of brain-injury markers during acute ischemic stroke]. Eksperimental'naia i klinicheskaia farmakologiia. 2012;75(3):7-9

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PMID: 22679745

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