Insulin-like growth factors in the peripheral nervous system.

A. Alfred Taubman Medical Research Institute, University of Michigan, 109 Zina Pitcher Place, 4019 AAT-BSRB, Ann Arbor, MI 48109, USA.

Endocrinology and metabolism clinics of North America 2012 Jun

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Insulin-like growth factors (IGFs) play an integral role in development, growth, and survival. This article details the current understanding of the effects of IGFs in the peripheral nervous system (PNS) during health and disease, and introduces how the IGF system regulates PNS development and impacts growth and survival of PNS cells. Also discussed are implications of IGF signaling in neurodegeneration and the status and prospects of IGF therapies for PNS conditions. There is substantial support for the application of IGF therapies in the treatment of PNS injury and disease. Copyright © 2012 Elsevier Inc. All rights reserved.

Citation

Stacey A Sakowski, Eva L Feldman. Insulin-like growth factors in the peripheral nervous system. Endocrinology and metabolism clinics of North America. 2012 Jun;41(2):375-93, vii